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Role of Metoprolol in the management of pre-hospital phase Of acute coronary syndrome

Metfine XL (Metoprolol succinate)

Promising role of metoprolol succinate in the management of pre-hospital phase of acute coronary syndrome

Acute coronary syndrome comprises clinical conditions ranging from angina, non-ST-segment elevation myocardial infarction and ST-segment elevation myocardial infarction which poses emergency and requires early and effective management. In the current study, role of metoprolol succinate (MS) and thrombolytic therapy was assessed in patients with acute coronary syndrome in the pre-hospital phase.

The results demonstrated:

  • After 60 min following the administration of MS, decrease in the intensity of pain was observed. Severe pain was found to be reduced by 54.1% whereas 16.1% reduction was observed in moderate pain
  • In addition, systolic arterial pressure (SAP) declined by 35.7 mmHg while 16.8 mmHg reduction was seen in diastolic arterial pressure (DAP)
  • The heart rate (HR) also diminished by 25.1 beats/min
  • After 90 and 180 min following the intake of MS, 21.8% and 25.3% of the patients showed positive dynamics of ST segment, respectively
  • Furthermore, the height of the ST segment was found to be normal in 18.4 and 31.0% of the patients, respectively
  • No evidence of death was reported from heart rupture by MS therapy in comparison to 39.1% of the patients who received standard thrombolytic therapy.

"MS therapy is effective in the management of pre-hospital stage in patients with acute coronary syndrome"

Thus, the above results suggest that MS therapy is effective in the management of pre-hospital stage in patients with acute coronary syndrome as it can reduce the intensity of pain. Moreover, MS therapy can cause decline in various parameters such as HR, DAP and SAP and help in amelioration of heart ruptures.

Source: Vertkin AL, Morozov SN, Fedorov AI. Experience in the pre-hospital treatment of acute coronary syndrome with metoprolol succinate. Klin Med (Mosk). 2013;91(3):31-5.